Co-disposition of chitosan nanoparticles by multi types of hepatic cells and their subsequent biological elimination: the mechanism and kinetic studies at the cellular and animal levels
Li-Qun Jiang,1 Ting-Yu Wang,1 Yun Wang,1 Zi-Yao Wang,1 Yu-Ting Bai1,21Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, China; 2School of Stomatology, Xuzhou Medical University, Xuzhou, ChinaBackground: The clearance of nanomaterials (NMs) from the liver is essential for clinic